B. Braun Clinus & EasyComp Alternative: MyTotalMix for Hospital Pharmacy
Clinus and EasyComp are two B. Braun programs built around clinical nutrition. According to the vendor's materials, Clinus simplifies and optimizes the prescription of clinical nutrition and offers a closed loop from prescription to administration - it writes the admixture composition as a QR code on the label, read by the same manufacturer's APEX compounder. EasyComp is GMP-validated software for evaluating the physicochemical compatibility of parenteral nutrition regimens for adult and pediatric patients. Together with the APEX compounder they form a single-manufacturer ecosystem - analogous to the Baxter Abacus + ExactaMix pairing. MyTotalMix is often considered as an alternative by hospital pharmacies that want one standalone software layer for the entire TPN process - with explicit ESPGHAN dose validation, an audit trail, and RBAC - independent of the compounder manufacturer.
Last updated: July 2, 2026
Clinus and EasyComp vs. MyTotalMix: two programs vs. one system
In the B. Braun stack, the parenteral nutrition process is split across products: Clinus handles clinical nutrition prescribing and generates the QR code for the APEX compounder, while EasyComp evaluates the admixture's physicochemical compatibility - checking whether a given composition will be stable and, per the vendor, suggesting corrective measures when it isn't. EasyComp is also adapted per country (local product database and language), and the vendor directs availability questions to the local subsidiary. MyTotalMix runs the same process in one system: from the physician's order, through dose validation against ESPGHAN limits and pharmacist verification, to the 2-in-1/3-in-1 admixture formula passed to the compounder. In fairness, the APEX compounder itself isn't fully closed on the input side: the vendor states it can read prescriptions (PAT files or QR codes) from several established prescription programs, not only Clinus. The vendor's materials do not, however, describe Clinus or EasyComp working with other manufacturers' compounders, nor the licensing model for these programs separately from the hardware.
Dose validation: physicochemical compatibility vs. ESPGHAN guidelines
EasyComp focuses on the physicochemical stability of the admixture - its stated scope is evaluating ingredient compatibility based on laboratory tests that define a stability window, for adult and pediatric patients. That's an important, but different, dimension of safety from clinical dose validation. B. Braun's public materials on Clinus, EasyComp, and APEX don't reference ESPGHAN or any other named clinical dosing guidelines, nor do they describe separate pathways for neonates and infants. In MyTotalMix, ESPGHAN-based dose validation is the explicitly stated foundation of the system: limits configured per organization, separate pathways for adults, older children, infants, and neonates, and pharmacist verification as a step in the process - alongside consistency checks on the admixture itself.
Audit trail, RBAC, and HIS integration
Publicly available vendor materials about Clinus and EasyComp don't describe a change audit trail, order versioning, or granular access control (RBAC). On hospital-system integration, the vendor states only that Clinus connected to a HIS also includes documentation to ensure error-free transcription of the regimen - with no technical detail. In MyTotalMix these elements are part of the architecture: a full change audit trail with prescription and order versioning, RBAC with pharmacist, technician, and admin roles, and HIS integration over API as an option arranged individually with each hospital - the system runs standalone and doesn't require integration as a deployment condition. On top of that come 15 years of domain development in TPN, with the current version of MyTotalMix being a full code rewrite on a modern technology stack.
MyTotalMix vs. B. Braun Clinus/EasyComp - compared across eight dimensions
This comparison relies solely on B. Braun's publicly available materials about Clinus, EasyComp, and the APEX compounder (the European/global stack; the US products TPN Manager and PINNACLE are a separate stack and aren't compared here). Where the vendor's materials don't provide detail, that is explicitly noted.
| Dimension | MyTotalMix | B. Braun Clinus/EasyComp |
|---|---|---|
| Product scope | One system: order, dose validation, pharmacist verification, formula to the compounder | Two programs: Clinus (clinical nutrition prescribing, QR for APEX) and EasyComp (physicochemical compatibility evaluation) |
| Hardware dependency | Device-agnostic, plugs into the compounders you already own | Developed around the same manufacturer's APEX compounder; per the vendor, APEX also reads orders from other prescription programs (PAT files/QR), but Clinus/EasyComp working with third-party hardware is not described publicly |
| ESPGHAN dose validation | ESPGHAN limits configurable per organization, separate pathways for adults, children, infants, and neonates | Vendor materials don't reference ESPGHAN or other named dosing guidelines |
| Admixture compatibility | Composition consistency checks as part of order validation | EasyComp: GMP-validated physicochemical stability evaluation based on laboratory tests, with suggested corrective measures |
| HIS integration | Optional: orders are entered directly in the system, with API integration arranged individually with each hospital | Vendor mentions Clinus working with a hospital information system (regimen documentation); technical detail not described publicly |
| Audit trail & versioning | Full change audit trail, prescription and order versioning | Vendor materials don't publicly describe an audit trail or order versioning |
| Access control | RBAC with pharmacist, technician, and admin roles | Vendor materials don't publicly describe an access control model |
| Availability in Poland | Built and developed in Poland, around the realities of the Polish hospital pharmacy | EasyComp is adapted per country (product database, language); the vendor directs availability questions to the local subsidiary - a Polish Clinus/EasyComp product page is not publicly available |
When Clinus and EasyComp may be the better choice
The B. Braun stack has a natural advantage where the hospital pharmacy runs an APEX compounder or plans to buy one: the Clinus-APEX QR integration is factory-made, and EasyComp brings GMP-validated physicochemical stability evaluation based on the manufacturer's laboratory tests - real value, especially with unusual compositions. One vendor for hardware and software also means one service contract. MyTotalMix earns its place where the pharmacy wants a single standalone system for the entire TPN process and purchasing independence: it runs (or wants the option to run) compounders from different manufacturers, needs explicit ESPGHAN dose validation with separate pathways from neonate to adult, requires a full change audit trail, versioning, and RBAC, and wants to enable HIS integration on its own terms - not as a starting requirement. For a pharmacy in Poland, a system developed locally around the realities of the domestic hospital also matters.
Common questions about MyTotalMix as an alternative to B. Braun Clinus and EasyComp
- How is MyTotalMix different from the Clinus + EasyComp pairing?
- B. Braun splits the process across two programs: Clinus handles clinical nutrition prescribing and generates the QR code for the APEX compounder, while EasyComp evaluates the admixture's physicochemical compatibility. MyTotalMix runs the entire process in one system - from the physician's order, through ESPGHAN dose validation and pharmacist verification, to the 2-in-1/3-in-1 admixture formula for the compounder - and is independent of the hardware manufacturer.
- Do Clinus and EasyComp only work with the APEX compounder?
- The vendor's materials describe Clinus and EasyComp within the APEX compounder ecosystem (Clinus writes the composition as a QR code read by APEX, and EasyComp is integrated with APEX). APEX itself, per the vendor, also reads orders from several other prescription programs, but Clinus or EasyComp working with other manufacturers' compounders is not described publicly. MyTotalMix is designed to plug into the hardware the pharmacy already operates.
- Do Clinus or EasyComp validate doses against ESPGHAN guidelines?
- B. Braun's publicly available materials on Clinus, EasyComp, and APEX don't reference ESPGHAN or any other named clinical dosing guidelines. EasyComp states physicochemical stability evaluation of admixtures for adults and children - a different dimension of safety from clinical dose validation. In MyTotalMix, ESPGHAN limits are the explicitly stated basis of validation, configured per organization.
- Does MyTotalMix check admixture compatibility (stability) like EasyComp?
- MyTotalMix checks the consistency of the admixture composition as part of order validation and pharmacist verification. EasyComp is a specialized tool for physicochemical stability evaluation based on the manufacturer's laboratory tests - if your pharmacy needs exactly that scope of stability testing, compare both approaches side by side in a demo, using your own formulas.
- Does deploying MyTotalMix require a HIS integration?
- No. MyTotalMix runs standalone, and nutrition orders are entered directly in the system. HIS integration is possible over API and arranged individually with each hospital - it's an option, not a deployment requirement.
- Do we need to replace our compounder to deploy MyTotalMix?
- No. MyTotalMix is independent of the compounder manufacturer and plugs into the hardware and label printers the pharmacy already runs, over barcode and OAuth. A pharmacy running an APEX compounder or another device doesn't need to replace it.
See MyTotalMix as an alternative to Clinus and EasyComp
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